For many biologists, statistics are an anathema; but statistical analysis of quantitative and qualitative data is of considerable importance. Although spreadsheet software provides a diverse range of statistical tools, users are often unsure which technique should be used. This book provides the basic statistical theory and practice to understand the types of tests frequently needed for the assessment of microbiological data. No prior knowledge of statistical techniques is required.Even when data can be given to a professional statistician for analysis, the microbiologist needs to have at least a general understanding of the underlying basis of statistical procedures in order to communicate effectively with the statistician. The book contains many worked examples to illustrate the use of the techniques and provides a plethora of references both to standard statistical works and to relevant original scientific papers on food microbiology.* Basil Jarvis has had many years of experience in academic, research and industrial food microbiology and is a Past President of the Society for Applied Microbiology. He has published several edited books and more than 200 scientific articles concerned with food microbiology. * NEW to this edition - chapters on Measurement Uncertainty in Microbiology, Statistical Process Control, Food Safety Objectives, Risk Assessment and Microbiological Criteria and a chapter on Validation of Microbiological Methods by Dr Sharon Brunelle, AOAC consultant.* Includes additional figures and tables together with many worked examples to illustrate the use of specific procedures in the analysis of data obtained in the microbiological examination of foods.
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements, responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. The control of biological processes, such as cellular growth and differentiation, is dependent on how the genetic material within a cell is expressed. The cellular physiology of mRNAincluding mRNA processing, transport, localization, and turnoveris central to the process of gene expression.Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway. Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover which are central to the process of gene expression.Offers step-by-step lab instructions including necessary equipment and reagents
It has widely been recognized that submodular functions play essential roles in efficiently solvable combinatorial optimization problems. Since the publication of the 1st edition of this book fifteen years ago, submodular functions have been showing further increasing importance in optimization, combinatorics, discrete mathematics, algorithmic computer science, and algorithmic economics, and there have been made remarkable developments of theory and algorithms in submodular functions. The 2nd edition of the book supplements the 1st edition with a lot of remarks and with new two chapters: "Submodular Function Minimization" and "Discrete Convex Analysis." The present 2nd edition is still a unique book on submodular functions, which is essential to students and researchers interested in combinatorial optimization, discrete mathematics, and discrete algorithms in the fields of mathematics, operations research, computer science, and economics.Key features:- Self-contained exposition of the theory of submodular functions.- Selected up-to-date materials substantial to future developments.- Polyhedral description of Discrete Convex Analysis.- Full description of submodular function minimization algorithms.- Effective insertion of figures.- Useful in applied mathematics, operations research, computer science, and economics.- Self-contained exposition of the theory of submodular functions.- Selected up-to-date materials substantial to future developments.- Polyhedral description of Discrete Convex Analysis.- Full description of submodular function minimization algorithms.- Effective insertion of figures.- Useful in applied mathematics, operations research, computer science, and economics.
This dissertation was aimed to describe significant changes on the level of messenger RNA upon the concentration modification of a feed component in animal diets. In addition, the gene expression analysis with high-density microarrays was established with differently fed animals. The book describes the detailed setup of the experiment from the animal diet over the tissue and sample preparation to the analysis of the gene expression data and the detection of regulatory transcription factors. The thesis gives important tips and tricks for genomics in animal nutrition with living animals. For the selenium experiment Sel-Plex®(Alltech Inc.), a selenized yeast, was supplemented to the broiler diet. Subsequently to the gene expression analysis in the liver, several altered protein activities and fatty acid concentration changes could be proven. In the second and third project alterations on the gene expression level could be shown upon the addition of mycotoxin-contaminated wheat and the myctoxin-binder Mycosorb® (Alltech Inc.). The differently expressed genes were assigned to previous results and several causal genes and transcription factors of detrimental effects were identified.
Handbook of Culture Media for Food Microbiology, Second Edition,37
Methods in Applied Soil Microbiology and Biochemistry,
DESCRIPTION:Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Articles in this volume discuss ion transport;ocular aquaporins and aqueous humor dynamics;the role of Ggap junction channels in the ciliary body secretory epithelium; regional dependence of inflow; functional modulators linking Iinflow with outflow of aqueous humor; aqueous humor outflow resistance; aqueous humor dynamics; the effects of circulatory events on aqueous humor inflow and intraocular pressure; retinal ganglion cells and glaucoma; what functional genomics is teaching us about intraocular pressure regulation and glaucoma;molecular approaches to glaucoma; outflow signaling mechanisms and new therapeutic strategies for the control of intraocular pressure.*Guest edited by cell membrane experts*Dynamic and thorough coverage of all aspects of the aqueous humor from inflow to outflow*Provides the latest teachings on genomics and glaucoma*Highlights new therapeutic strategies for the control of intraocular pressure
Engineering Design Methods Second Edition: Starteg ies and Tactics for Product Design Chapter 9
Precise numerical analysis may be defined as the study of computer methods for solving mathematical problems either exactly or to prescribed accuracy. This book explains how precise numerical analysis is constructed. It includes a CD-ROM which contains executable Windows XP programs for the PC and which demonstrates how these programs can be used to solve typical problems of elementary numerical analysis with precision. The book also provides exercises which illustrate points from the text and references for the methods presented.A· Clearer, simpler descriptions and explanations ofthe various numerical methodsA· Windows based softwareA· Two new types of numerical problems; accurately solving partial differential equations with the included software and computing line integrals in the complex plane.
Telomerase activity, hTERT and Survivin these markers with combined urinary cytology may give more sensitive diagnostic clues in bladder malignancies and by using this approach diagnosis of low grade tumor are also possible which was not detectable by earlier nioninvasive methods. Diagnostic future of telomerase is very positive because today it is confirmed that near about all tumor cells express telomerase, so telomerase can help in early diagnosis and this way patients can get better treatment.
Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.
This book provides a survey of the frontiers of research in the numerical modeling and mathematical analysis used in the study of the atmosphere and oceans. The details of the current practices in global atmospheric and ocean models, the assimilation of observational data into such models and the numerical techniques used in theoretical analysis of the atmosphere and ocean are among the topics covered. . Truly interdisciplinary: scientific interactions between specialties of atmospheric and ocean sciences and applied and computational mathematics . Uses the approach of computational mathematicians, applied and numerical analysts and the tools appropriate for unsolved problems in the atmospheric and oceanic sciences. Contributions uniquely address central problems and provide a survey of the frontier of research